Second Century (101-200) the sub-Apostolic Age
More commonly referred to as the "sub-Apostolic age", begins and ends with the second century.
- 105 Plutarch, bishop of Byzantium (Constantinople)
- 107 c, Symeon the Zealot (Luke 6:15 and Acts 1:13), 2nd bishop of Jerusalem, is crucified  at the age of 120, location disputed; c, Ignatius, 3rd bishop of Antioch, martyred in Rome (or c, 115).
- 108-124 (3rd) Persection of Christians under Emperor Trajan and continuing under Emperor Hadrian.
- c.120 Martyrdom of Eleutherios and his mother Anthia.
- c.130 Death of Apostle Quadratus, of the Seventy; Papias, bishop of Heriopolis and apostolic father.
- 138 Telephorus, bishop of Rome, the only 2nd-century pope who's martyrdom is historically verifiable.
- 155 Polycarp, bishop of Smyrna, martyred by being burned to death in the arena in Smyrna.citation needed
- 160 Marcian, heretic, dies.
- 165 Valentium, Gnostic heretic, dies; Justin Martyr and disciples denounced as Christian, scourged and beheaded for refusing to sacrifice; Peregrinus Proteus becomes Christian and leader of a synagogue, then takes up the life of a Cynic. He ends his life by burning himself on a pyre at the Olympiad of 165 in Athens.
- 177-180 (4th) Persecutions of Christians under Emperor Marcus Aurelius (161-180).
- 177 Pothinus, bishop of Lyons, Blandina, Ponticus at others martyr in Lyons dying in the "odor of sanctity".
- 180 Dyfan of Merthyr first martyr in British Isles, May 14; The twelve Scillitan Martyrs  executed in Scillium of North Africa the earliest documented martyrdom of the Church of Africa, July 17; Marcus Aurelius dies of plague.
- 190 Melito, bishop of Sardis, dies.
- c.200-202 Irenaeus of Lyons dies, possibly martyrdom.
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- The crucifixion of Symeon possibly includes Jewish involvement: From Eusebius' Church History 3.32.4: "And the same writer says that his accusers also, when search was made for the descendants of David, were arrested as belonging to that family." Sidenote 879: "This is a peculiar statement. Members of the house of David would hardly have ventured to accuse Symeon on the ground that he belonged to that house. The statement is, however, quite indefinite. We are not told what happened to these accusers, nor indeed that they really were of David’s line, although the ὡσ€ν with which Eusebius introduces the charge does not imply any doubt in his own mind, as Lightfoot quite rightly remarks. It is possible that some who were of the line of David may have accused Symeon, not of being a member of that family, but only of being a Christian, and that the report of the occurrence may have become afterward confused."
- The account of Scillitan Martyrs is based on trial records, though it has been embellished with miraculous and apocryphal material.