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Monothelitism (a Greek loanword meaning "one will") is a particular teaching about how the divine and human relate in the person of Jesus, known as a Christological doctrine. Specifically, Monothelitism teaches that Jesus Christ had two natures but only one will. This is contrary to the orthodox interpretation of Christology, which teaches that Jesus Christ has two wills (human and divine) corresponding to his two natures. Monothelitism is a development of the Monophysitism position in the Christological debates. It enjoyed considerable support in the seventh century before being rejected as heretical at the Sixth Ecumenical Council in 680.

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