Matrona may refer to the following saints:
- Matrona of Thessalonica (March 27), +ca. 3rd/4th c.
- Matrona, Abbess of Constantinople (Matrona of Perge) (November 9), +ca. 510
- Matrona of Chios (October 20) and (July 15), +1462
- Matrona of Moscow (May 2), +1952