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The document failed to satisfy either side. All church leaders took offense at the emperor's open dictate of church policy. After two years of prevarication and temporializing by Acacius, the Pope of Rome, Felix III, in 484, condemned the document and excommunicated Acacius. Acacius in turn removed the name of Pope Felix from the [[diptychs]], effectively beginning the [[Acacian Schism]]. The [[excommunication]] was largely ignored in Constantinople, even after the death of Acacius in 489.
Zeno died in 491. His successor [[Flavius Anastasius|Anastasius I]], as emperor, was sympathetic to the non-Chalcedonians, but he accepted the Henoticon. However, Anastasius was unpopular because of his [[Miaphysitism|Miaphysite]] beliefs, and Vitalian, a Chalcedonian general, attempted to overthrow him in 514, but failed. Anastasius attempted to heal the [[schism]] with Pope Hormisdas of Rome, but this failed when Anastasius refused to recognize the excommunication of the now deceased Acacius. General Vitalian tried to overthrow the emperor for a second time, but he was defeated by loyal officers.
The schism caused by the Henoticon was officially settled in 519 when Emperor [[Justin I]] recognized the excommunication of Acacius and reunited the churches of Rome and Constantinople. However, the Patriarchates of Alexandria, Antioch, and Jerusalem split, forming both non-Chalcedonian and Chalcedonian [[see]]s.
