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A strong character, Saint Celestine was active against [[pelagianism]], he sent St. Germanus of Auxerre to Britain and St. Palladius to Ireland.
During this time, the heresy of [[Nestorius]] emerged. At a local Council in Rome in 430, St Celestine denounced this heresy and condemned Nestorius as a [[heretic]]. After the Council, St Celestine wrote a letter to St [[Cyril of Alexandria|Cyril, Archbishop of Alexandria]] ([[January 18]]), stating that if Nestorius did not renounce his false teachings after ten days, then he should be [[deposition|deposed ]] and [[excommunication|excommunicated]].
St Celestine also sent a series of letters to other churches, [[Constantinople]] and [[Antioch]], in which he unmasked and denounced the [[Nestorianism|Nestorian]] heresy.