As a Bishop he preached incessantly not only about the need to live Orthodoxy but against the perils of the “[[Living Church]]”. The latter was a defiled heretic sect propagated by the communist regime. He is credited with 1250 sermons over thirty-eight years of priesthood and episcopal service of which 750 were preserved in twelve volumes. When he practiced surgery from this point on he wore his bishop's cassock in the operating room and refused to perform surgery without an icon.
As the Lenin, Stalin, and Khrushchev regime came and went Saint Luke’s persecutions and frequent transfers only increased his popularity. Despite public slander he was known as an unselfish, loving, physician and spiritual father. This posed a great propaganda threat to each regime and towards the end of his life Saint Luke was restricted in his travels and his medical responsibilities to remedial services. The latter was also in God’s plan as toward the end of his life Saint Luke lost his vision to glaucoma. He could now devote his time exclusively to matters of faith. He performed many healing miracles and had many spiritual children. Toward the end of his life he was worried if it would be permitted to chant “Holy God” at his funeral. He last liturgized on the feast of the Nativity of Christ in 1960 and his last sermon on Forgiveness Sunday. His repose was [[June 11]], 1961, the day of commemoration for “All Saints who shone forth in the Land of Russia”.
The government made every effort to make Saint Luke’s funeral as inconspicuous as possible. Busses were provided to hurry the funeral procession along the side-streets to the gravesite so there would be little fanfare and recognition.
To the dismay of the government and to avoid an uprising, they conceded to allow the funeral to proceed for three and a half hours without interference. The roads were full and cars stopped everywhere. People had climbed on balconies, onto rooftops of houses. Such a funeral was a tribute of honor. The authorities wanted a silent event. It was witness to God’s Glory that throughout the walk there was a constant chant of “Holy God, Holy Mighty, Holy Immortal have mercy on us”. Saint Luke’s prayers to have Holy God chanted at his funeral during the atheistic times were answered!
On March 17th 1996, St. Luke's remains were disinterred, with an estimated 40,000 people taking part. It is said that an indescribable aroma arouse from his relics, while his heart was discovered incorrupt, a testament to the great love he bore towards Christ and his fellow men. Three days later on March 20th 1996, his relics were transferred to the Church of the Holy Trinity.