On [[October 1]], 1825, Jacob was [[tonsure]]d a sub-deacon. He married Anna Simeonovna, a Russian woman perhaps of a Creole background as was he, and then in
1926 he graduated from the seminary with certificates in history and theology. With graduation he was ordained a [[deacon]] on [[October 31]], 1826 and assigned to the Holy Trinity-St. Peter Church in Irkutsk. Two years later, [[Archbishop]] Michael ordained Jacob to the holy [[priest]]hood on [[March 4]], 1828. Archbishop Michael had earlier ordained John Veniaminov (St. Innocent) to the priesthood. With his elevation to the priesthood, Father Jacob began to yearn to return to his native Alaska to preach the Word of God.
Upon departing, Archbishop Michael gave Father Jacob two [[antimension|antimensia]], one for use in the new church that Father Jacob planned to built on Atka, and the other for use in Father Jacob's missionary travels. After a [[molieben]], Father Jacob and his party set off for Alaska on [[May 1]], 1828. The travelers included Father Jacob, Anna his wife, and his father Yegor who had been tonsured reader for the new Atka Church. This journey, which was always hard, took over year to complete, which was completed on [[June 15]], 1829.
On [[December 30]], 1844, St. Innocent appointed him head of the new Kvikhpak Mission to bring the light of Christ to the people along the Yukon River. With two young Creole assistants, Innokentii Shayashnikov and Konstantin Lukin, and his nephew Vasili Netsvetov, Father Jacob established his headquarters in the Yup'ik Eskimo village of Ikogmiute. From there, now known as Russian Mission, he traveled to the settlements for hundreds of miles along the Yukon and Kuskokwim Rivers, visiting the inhabitants of settlements along the way. For the next twenty years he learned new languages, met new people and cultures, invented another alphabet, and built more churches and communities. At the invitation of the native leaders he traveled as far as the Innoko River baptizing hundreds from many, and often formerly hostile, tribes. He continued even as his health deteriorated.
Yet the devil's presence came to stir up spurious and slanderous charges against him in 1863. To clear the air his Bishop Peter called him to Sitka where he was cleared of all the charges. As his health worsened he remained in Sitka serving at the Tlingit chapel until his death on [[July 26]],
1964. He was 60 years old.
During his last missionary travels in the Kuskokwim/Yukon delta region he is remembered for baptizing 1,320 people and for distinguishing himself as the evangelizer of the Yup'k Eskimo and Athabascan peoples.