→Second Century (101-200) the sub-Apostolic Age
*160 ''Marcian, heretic, dies.''
*165 ''Valentium, Gnostic heretic, dies''; [[Justin Martyr]] and disciples denounced as Christian, scourged and beheaded for refusing to sacrifice; ''Peregrinus Proteus becomes Christian and leader of a synagogue, then takes up the life of a Cynic. He ends his life by burning himself on a pyre at the Olympiad of 165 in Athens.''
;177-180 (4th) Persecutions of Christians under Emperor Marcus Aurelius (161-180).
*177 Pothinus, bishop of Lyons, Blandina, Ponticus at others martyr in Lyons dying in the "odor of sanctity".